The TurboBlotter system is a rapid downward blotting device for high-resolution transfer of DNA and RNA. The conventional Northern/Southern transfer stack has been turned upside down in order to take advantage of gravity. No heavy weights are required on the top of the transfer stack, eliminating the messy set-up of standard upward capillary transfers. The TurboBlotter System offers greater speed, target resolution, and convenience versus traditional blotting procedures. Alkaline DNA transfers can be performed in as little as one hour, while neutral (SSC) transfers of DNA and RNA take only three hours. Nytran SPC, wicks and blotter stacks for five transfers from 15cm x 20cm gel size. Each transfer uses one sheet of Nytran SPC, one wick of 3MM Chr, and a blotter stack composed of eight sheets of 3MM Chr and twenty sheets of GB004. Each TurboBlotter Kit or TurboBlotter refill contains five sets of these materials, enough for five transfers.